Seizing an Opportunity for the Endocannabinoid System

Seizing an opportunity for the endocannabinoid system.

Exogenous cannabinoids can limit seizures and neurodegeneration, and their actions are largely mimicked by endogenous cannabinoids (endocannabinoids). Endocannabinoids are mobilized by epileptiform activity and in turn influence this activity by inhibiting synaptic transmission; both excitatory and some inhibitory synapses can be suppressed, leading to potentially complex outcomes. Moreover, th...

Seizing the Digitalization Opportunity

Seizing the Opportunity: Exploiting Web Aggregation

This paper examines the development of web aggregators, entities that collect information from a wide range of sources, with or without prior arrangements, and add value through post-aggregation services. New Web-page extraction tools, context sensitive mediators, and agent technologies have greatly reduced the barriers to constructing aggregators. We predict that aggregators will soon emerge i...

Seizing the opportunity to close the cancer divide.

On which of the battles not yet won should we focus attention when reviewing the global response to the challenge of cancer? Prevention and successful treatment are possible for many of the cancers that kill poor people of all ages globally. But to respond to this opportunity, we fi rst need to dispel the myths that surround cancer and poverty. Between 1990 and 2010 the global burden of disease...

The endocannabinoid system: an overview

Upon the identification of anandamide (AEA) in the porcine brain, numerous studies contributed to the current state of knowledge regarding all elements that form the "endocannabinoid system (ECS)."How this complex system of receptors, ligands, and enzymes is integrated in helping to regulate fundamental processes at level of central nervous and peripheral systems and how its regulation and dysr...